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Research summary: BPC-157 (Body Protection Compound-157) is a synthetic 15-amino-acid peptide, sequence Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val, derived from a protein in human gastric juice. It is among the most studied peptides in preclinical literature, with much of the published work originating from Dr. Predrag Sikiric’s group at the University of Zagreb examining tissue-repair and systemic-signaling models. Sold for laboratory research use only.
BPC-157 (Body Protection Compound-157) is a synthetic 15-amino acid peptide derived from a protein found in human gastric juice. It has become one of the most studied peptides in preclinical research, with an extensive body of literature examining its effects on tissue repair and systemic signaling.
What Is BPC-157?
BPC-157’s amino acid sequence is Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val. It is sometimes referred to as PL 14736 in pharmaceutical research. The majority of published research originates from the University of Zagreb group led by Dr. Predrag Sikiric.
Key Research Areas
Tendon and ligament: Studies including work by Pevec et al. and Staresinic et al. examined transected tendons and ligaments in rat models, observing accelerated fibroblast activity and collagen organization versus controls.
Gastrointestinal tissue: Given its origin from gastric juice proteins, BPC-157 has been studied extensively in GI tissue models, examining mucosal integrity in esophageal, gastric, and intestinal injury models.
Nitric oxide signaling: A significant body of research has investigated BPC-157’s interaction with the nitric oxide (NO) system, including dopaminergic and serotonergic pathway studies in animal models.
Bone and cartilage: Several studies have examined BPC-157 in bone defect and cartilage damage models, with findings published in the Journal of Orthopaedic Research and related journals.
Administration Routes Studied
Research protocols have used intraperitoneal injection, intragastric administration, and subcutaneous delivery in rodent subjects. Route of administration has been noted as a variable in some studies’ observed outcomes.